Aromatase Inhibitors – Simple Facts You Need

When doctors talk about cutting estrogen, you’ll often hear the term aromatase inhibitor. These pills block the enzyme that turns testosterone into estrogen, so your body makes less of the hormone. Less estrogen can slow down or stop cancers that feed on it, especially many types of breast cancer. The idea sounds technical, but the goal is simple: starve the tumor of the fuel it loves.

Who Gets Prescribed an Aromatase Inhibitor?

Mostly post‑menopausal women with estrogen‑receptor‑positive breast cancer. After surgery or radiation, doctors add an aromatase inhibitor to keep the cancer from coming back. Some men with hormone‑sensitive prostate issues also take these drugs, though that’s less common. If you’re still having periods, your doctor will likely choose a different hormone therapy because aromatase inhibitors work best when your ovaries have stopped producing estrogen naturally.

Typical Doses and How to Take Them

Three drugs dominate the market: letrozole (Femara), anastrozole (Arimidex), and exemestane (Aromasin). The usual daily dose is one tablet – 2.5 mg for letrozole, 1 mg for anastrozole, and 25 mg for exemestane. Take them with or without food; consistency matters more than timing. If you miss a dose, just take it as soon as you remember unless it’s almost time for the next one. Don’t double up.

While the tablets are short, the effects stick around. Blood tests may show estrogen levels dropping within a week, but you won’t feel a dramatic change right away. Your doctor will likely check bone density and cholesterol after a few months because long‑term use can affect both.

Side effects vary but are usually manageable. Joint pain (often called “arthralgia”) tops the list, followed by hot flashes, fatigue, and mild nausea. Some people notice their mood shifting or having trouble sleeping. Because estrogen also helps keep bones strong, doctors often prescribe calcium and vitamin D supplements, plus occasional bone‑strengthening meds if you’re at risk for osteoporosis.

If anything feels off – severe swelling, sudden weight gain, or unusual bruising – call your doctor right away. Those could signal rare but serious issues like blood clots or liver problems. Most side effects ease after the first few months as your body adjusts.

Bottom line: aromatase inhibitors are powerful tools for hormone‑driven cancers, but they need a partner in monitoring. Keep appointments, report new symptoms, and stay on the prescribed schedule. With the right care, these pills can help many people stay cancer‑free for years.